Neural signature of the conscious processing of auditory regularities

Document Type: 
Article
Article Type: 
Experimental
Disciplines: 
Neuroscience
Topics: 
Neural Correlates of Consciousness
Keywords: 
consciousness/neuroimaging/neurophysiology/patients
Deposited by: 
Dr. Tristan Bekinschtein on 14 February 2009
Date of Issue: 
2009
Authors: 
Tristan A. Bekinschtein, Stanislas Dehaene, Benjamin Rohaut, Francois Tadel, Laurent Cohen, Lionel Naccache
Journal/Publication Title: 
PNAS
Volume: 
106
Issue Number: 
5
Page Range: 
1672-1677
Alternative URL: 
http://trisbek.googlepages.com/Bekinschtein_neuralsignaturesoftheco.pdf
Publish status: 
Published
Abstract: 
Can conscious processing be inferred from neurophysiological measurements? Some models stipulate that the active maintenance of perceptual representations across time requires consciousness. Capitalizing on this assumption, we designed an auditory paradigm that evaluates cerebral responses to violations of temporal regularities that are either local in time or global across several seconds. Local violations led to an early response in auditory cortex, independent of attention or the presence of a concurrent visual task, whereas global violations led to a late and spatially distributed response that was only present when subjects were attentive and aware of the violations. We could detect the global effect in individual subjects using functional MRI and both scalp and intracerebral event-related potentials. Recordings from 8 noncommunicating patients with disorders of consciousness conīŦrmed that only conscious individuals presented a global effect. Taken together these observations suggest that the presence of the global effect is a signature of conscious processing, although it can be absent in conscious subjects who are not aware of the global auditory regularities. This simple electrophysiological marker could thus serve as a useful clinical tool.
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